In 1893, the synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMS) via three-component condensation reaction of an aromatic aldehyde, urea and ethyl acetoacetate was reported for the first time by P. Biginelli. In the past decades, such Biginelli-type dihydropyrimidones have received a considerable amount of attention due to the interesting pharmacological properties associated with this heterocyclic scaffold. In this review oxazolo [3,2-a] and pyrimido [2,1-b][1,3]oxazine have been prepared from 3,4-dihydropyrimidin-2(1H)-ones.Then I was focused my work to make new derivatives of oxazolopyrimidine, and pyrimidooxazine, having sulfonyl linkage and to check their Antibacterial and Antifungal activity . Purity of each compounds were checked by TLC using silica gel plate. All newly synthesized compounds were characterized by IR.
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